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Mounjaro contains tirzepatide, which targets both GLP-1 and GIP receptors for added metabolic benefits
Tregs take up lactate via MCT1 (encoded by Slc16a1), convert it to pyruvate for entry into the TCA, and generate phosphoenolpyruvate (PEP) via PEP carboxykinase (PEPCK), which feeds back to promote gluconeogenesis and nucleotide synthesis to support Treg proliferation
10.1128/MCB.00578-15 126 SandersL
Understanding what to expect can help patients and clinicians optimize outcomes while minimizing adverse effects
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